Yves Saint Laurent Opium Homme 100ml EDT Men Spray

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E. Guerra Doce (January 1, 2006). "Evidencias del consumo de drogas en Europa durante la Prehistoria". Trastornos Adictivos (in Spanish). 8 (1): 53–61. doi: 10.1016/S1575-0973(06)75106-6. Archived from the original on May 15, 2008 . Retrieved May 10, 2007. (includes image) Merlin, M. D. (September 2003). "Archaeological Evidence for the Tradition of Psychoactive Plant Use in the Old World". Economic Botany. 57 (3): 295–323. doi: 10.1663/0013-0001(2003)057[0295:aeftto]2.0.co;2. ISSN 0013-0001. JSTOR 4256701. S2CID 30297486 . Retrieved May 31, 2022. Liang, Bin; Lu, Hong (2013). "Discourses of drug problems and drug control in China: Reports in the People's Daily, 1946–2009". China Information. 27 (3): 302. doi: 10.1177/0920203X13491387. S2CID 147627658.

Duarte DF: [Opium and opioids: a brief history.]. Rev Bras Anestesiol. 2005 Feb;55(1):135-46. [ Article] Bradley, James (2009). The Imperial Cruise: a secret history of empire and war. Little, Brown and Company. pp. 274–275. ISBN 978-0-316-00895-2. Hubble D (October 1957). "Opium Addiction and English Literature". Medical History. 1 (4): 323–35. doi: 10.1017/s0025727300021505. PMC 1034310. PMID 13476921. Alfred W. McCoy (1972). "The politics of heroin in Southeast Asia". Archived from the original on October 7, 2007 . Retrieved September 24, 2007.

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The addictive character of opium is related to the binding to the μ-opioid receptors, which will activate dopaminergic neurons in the ventral tegmental area of the midbrain and thus, enhance the dopamine release in the nucleus accumbens. This mechanism involves the reward activity of the mesolimbic dopaminergic pathway. 10 Target

The Persian physician Abū ‘Alī al-Husayn ibn Sina ("Avicenna") described opium as the most powerful of the stupefacients, in comparison to mandrake and other highly effective herbs, in The Canon of Medicine. The text lists medicinal effects of opium, such as analgesia, hypnosis, antitussive effects, gastrointestinal effects, cognitive effects, respiratory depression, neuromuscular disturbances, and sexual dysfunction. It also refers to opium's potential as a poison. Avicenna describes several methods of delivery and recommendations for doses of the drug. [24] This classic text was translated into Latin in 1175 and later into many other languages and remained authoritative until the 19th century. [25] Şerafeddin Sabuncuoğlu used opium in the 14th-century Ottoman Empire to treat migraine headaches, sciatica, and other painful ailments. [26] Reintroduction to Western medicine [ edit ] Latin translation of Avicenna's Canon of Medicine, 1483 The earliest clear description of the use of opium as a recreational drug in China came from Xu Boling, who wrote in 1483 that opium was "mainly used to aid masculinity, strengthen sperm and regain vigor", and that it "enhances the art of alchemists, sex and court ladies". He also described an expedition sent by the Ming dynasty Chenghua Emperor in 1483 to procure opium for a price "equal to that of gold" in Hainan, Fujian, Zhejiang, Sichuan and Shaanxi, where it is close to the western lands of Xiyu. A century later, Li Shizhen listed standard medical uses of opium in his renowned Compendium of Materia Medica (1578), but also wrote that "lay people use it for the art of sex," in particular the ability to "arrest seminal emission". This association of opium with sex continued in China until the end of the 19th century. Nye, Gideon (1873). The morning of my life in China: comprising an outline of the history of foreign intercourse from the last year of the regime of honorable East India Company, 1833, to the imprisonment of the foreign community in 1839.As a Class A drug the maximum sentence for the possession of opium is 7 years. The maximum sentences for supply and/or production are life imprisonment, a fine or both. History Opium is most commonly smoked but can also be eaten raw, made into a pill or made into a tincture for drinking. Law Extensive textual and pictorial sources also show that poppy cultivation and opium consumption were widespread in Safavid Iran [42] and Mughal India. [43] England [ edit ]

Heydari, M; Hashempur, M. H.; Zargaran, A (2013). "Medicinal aspects of opium as described in Avicenna's Canon of Medicine". Acta medico-historica Adriatica. 11 (1): 101–12. PMID 23883087. Globally, opium has gradually been superseded by a variety of purified, semi-synthetic, and synthetic opioids with progressively stronger effects, and by other general anesthetics. This process began in 1804, when Friedrich Wilhelm Adam Sertürner first isolated morphine from the opium poppy. [100] [101] Modern vial of morphine first isolated from opium by Friedrich SertürnerPablo Bartholomew (1996). "Opium for the masses: photo essay on cultivation of opium in India". Archived from the original on July 1, 2007 . Retrieved June 15, 2007. Samrat Sharma (August 17, 2021). "Drug dollars: How Taliban's opium push helped oust the Afghan government". India Today . Retrieved August 19, 2021. Peter Ward Fay (November 9, 2000). The Opium War, 1840–1842: Barbarians in the Celestial Empire in the Early Part of the Nineteenth Century and the War by which They Forced Her Gates Ajar. Univ of North Carolina Press. pp.290–. ISBN 978-0-8078-6136-3. Donna Young (April 15, 2007). "Scientists Examine Pain Relief and Addiction". Archived from the original on December 6, 2007 . Retrieved June 6, 2007. Opium poppies are popular and attractive garden plants, whose flowers vary greatly in color, size and form. A modest amount of domestic cultivation in private gardens is not usually subject to legal controls. In part, this tolerance reflects variation in addictive potency. A cultivar for opium production, Papaver somniferum L. elite, contains 91.2 percent morphine, codeine, and thebaine in its latex alkaloids, whereas in the latex of the condiment cultivar "Marianne", these three alkaloids total only 14.0 percent. The remaining alkaloids in the latter cultivar are primarily narcotoline and noscapine. [114]

Finn AK, Whistler JL (December 2001). "Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal". Neuron. 32 (5): 829–39. doi: 10.1016/S0896-6273(01)00517-7. PMID 11738029. S2CID 16396686. Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. 1 Suzanne Carr (1995). "MS thesis". Archived from the original on November 8, 2009 . Retrieved May 16, 2007. (citing Andrew Sherratt)Hall, Wayne; Weier, Megan (2017). "Lee Robins' studies of heroin use among US Vietnam veterans". Addiction. 112 (1): 177. doi: 10.1111/add.13584. PMID 27650054. S2CID 206974500 . Retrieved July 26, 2022. Great Britain (1913). Agreement between Great Britain and Portugal for regulation of the opium monopolies of the colonies of Hong Kong and Macao. London, Printed for H.M. Stationery office. by Harrison and sons, ltd. Darke S, Zador D (December 1996). "Fatal heroin 'overdose': a review". Addiction. 91 (12): 1765–72. doi: 10.1046/j.1360-0443.1996.911217652.x. PMID 8997759.