MAGNE B6 MAX - 50 Capsules - is a Dietary Supplement containing in its Composition Magnesium and Vitamin B6, for People Suffering Weakness, Fatigue, Twitching eyelids and Muscle spasms

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Serine racemase which synthesizes the neuromodulator D-serine from its enantiomer is a PLP-dependent enzyme. The European Food Safety Authority (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA. For women and men ages 15 and older the PRI is set at 1.6 and 1.7mg/day, respectively; for pregnancy 1.8mg/day, for lactation 1.7mg/day. For children ages 1–14 years the PRIs increase with age from 0.6 to 1.4mg/day. [22] The EFSA also reviewed the safety question and set its UL at 25mg/day. [23] [24]

Vitamin B 6 is one of the B vitamins, and thus an essential nutrient. [1] [2] [3] [4] The term refers to a group of six chemically similar compounds, i.e., " vitamers", which can be interconverted in biological systems. Its active form, pyridoxal 5′-phosphate, serves as a coenzyme in more than 140 enzyme reactions in amino acid, glucose, and lipid metabolism. [1] [2] [3]Another study found that taking 75 mg of vitamin B6 daily during pregnancy decreased symptoms of anemia in 56 pregnant women who were unresponsive to treatment with iron ( 20). Two pathways for PLP are currently known: one requires deoxyxylulose 5-phosphate (DXP), while the other does not, hence they are known as DXP-dependent and DXP-independent. These pathways have been studied extensively in Escherichia coli [10] and Bacillus subtilis, respectively. Despite the disparity in the starting compounds and the different number of steps required, the two pathways possess many commonalities. [11] The DXP-dependent pathway:

a b c d "Vitamin B 6". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. May 2014. Archived from the original on 2018-03-14 . Retrieved 7 March 2017. Fanidi, A; Muller, DC; Yuan, J; Stevens, VL; Weinstein, SJ (January 2018). "Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)". Journal of the National Cancer Institute. 110 (1): 57–67. doi: 10.1093/jnci/djx119. ISSN 1460-2105. PMC 5989622. PMID 28922778. Above is the important information about the drug Magne B6. Patients can consult more and consult a doctor before using. While these results are promising, they’re limited by small sample size and short duration. More research on the safety and effectiveness of vitamin B6 in improving PMS symptoms is needed before recommendations can be made ( 25).Jayedi A, Zargar MS (2019). "Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies". Crit Rev Food Sci Nutr. 59 (16): 2697–707. doi: 10.1080/10408398.2018.1511967. PMID 30431328. S2CID 53430399. A three-month study in over 60 premenopausal women found that taking 50 mg of vitamin B6 daily improved PMS symptoms of depression, irritability and tiredness by 69% ( 23). Cooking, storage, and processing losses vary, and in some foods may be more than 50% depending on the form of vitamin present in the food. [3] Plant foods lose less during processing, as they contain pyridoxine, which is more stable than the pyridoxal or pyridoxamine forms found in animal-sourced foods. For example, milk can lose 30–70% of its vitamin B 6 content when dried. [15] The vitamin is found in the germ and aleurone layer of grains, so there is more in whole wheat bread compared to white bread wheat, and more in brown rice compared to white rice. [30] As of 2019, fourteen countries require food fortification of wheat flour, maize flour or rice with vitamin B 6 as pyridoxine hydrochloride. Most of these are in southeast Africa or Central America. The amounts stipulated range from 3.0 to 6.5mg/kg. An additional seven countries, including India, have a voluntary fortification program. India stipulates 2.0mg/kg. [31] Dietary supplements [ edit ] Vitamin B 6 is found in a wide variety of foods. In general, meat, fish and fowl are good sources, but dairy foods and eggs are not (table). [29] [30] Crustaceans and mollusks contain about 0.1mg/100 grams. Fruit (apples, oranges, pears) contain less than 0.1mg/100g. [30]