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Medina M, Izquierdo E, Ennahar S, et al. Differential immunomodulatory properties of Bifidobacterium longum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol. 2007;150:531–538. The effectiveness of probiotics in IBS depends on their composition, dose, and duration of administration. The importance of probiotic composition can be observed by comparing the results of the current study with those of our recently published RDBPC trial in a group of IBS patients [ 36]. Both studies were conducted according to the same protocol and were performed by the same research teams, but in the study published in 2020 IBS-D patients were treated with a multi-strain synbiotic preparation containing three Bifidobacterium species ( Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium bifidum), two Lactobacillus species ( Lactobacillus rhamnosus, Lactobacillus acidophilus), and short chain fructooligosaccharides as a prebiotic component. Although the administration of a synbiotic significantly decreased the total IBS-SSS score, it mainly improved the severity of flatulence but had no effect on the perception of pain. A comparison of the results of these two studies may indicate that the probiotic/synbiotic preparation should be matched to the dominant symptoms. Using specific strains can provide a more targeted and effective approach to gut health, butthe synergy between multi-strain combinations,and the broader range of effects theymay provide when used together, needs more research.Strain-specific probiotic therapy can certainly provide benefits for specific conditions, but as you can see there are no universal rules - for some individuals taking a single-strain probiotic like Saccharomyces boulardiiworks well, whilst for others a dual or multi-strain probiotic might be better. The quality of the probiotics strains used is by far the most important factor to consider when selecting the right supplement, and looking at the available clinical trials behind the strains will help you to select the right strain (or strains) for you or your clients. Do not use if safety seal is broken. Consult a healthcare professional prior to use if you are experiencing nausea, fever, vomiting, bloody diarrhea or severe abdominal pain. Stop use and consult a healthcare professional if symptoms of digestive upset, such as diarrhea, occur, worsen or persist beyond 3 days.
A study 2published in 2010 randomly assigned children with rotavirus to receive one of three treatments: oral rehydration therapy plus placebo; oral rehydration solution plus Saccharomyces boulardii, or oral rehydration solution plus a multi-strain probioticcontaining Saccharomyces boulardii in combination with Lactobacillus acidophilus, Lactobacillus rhamnosus, and Bifidobacterium longum. Multi-Strain 11 is Cyto-Matrix’s multistrain probiotic containing 9 different strains and a guaranteed 11 billion colony forming units (CFUs) per vegetable capsule. Over 70% of the probiotics found in Multi.Strain 11 are Lactobacillus rhamnosus, making the formula particularly indicated for the healthy balance of the immune system, the prevention and treatment of atopic concerns such as allergies and eczema, as well as common digestive complaints such as flatulence and bloating. Over a decade of clinical use by Canadian integrative healthcare practitioners has made Multi.Strain 11 one of the most trusted probiotic formulations in the country with strong anecdotal evidence to support its use. A general recommendation is to choose probiotic products with at least 1 billion colony-forming units and containing the genus Lactobacillus, Bifidobacterium, Bacillusor Saccharomyces boulardii, some of the most researched probiotics. Even then, you may have to delve deeper, as each genus of bacteria encompasses numerous strains that produce different results. It contains Lactobacillus rhamnosus and Bifidobacterium animalis in a delayed-release capsule. Capsules come in a moisture-controlled container that does not need to be refrigerated. Bacteria strains: Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium lactis, and more.people receive personalized supplements which ensure that the product they take meet their requirements If someone has disrupted their gut microbial balance, this is where a probiotic can be of benefit,” saysDr. Cresci. “But whether it’s really going to help and whether you’re taking the right one are the big questions out there.” Bacteria strains: Bifidobacterium lactis, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bacillus coagulans, and more. Hay Fever or seasonal allergies may range from being a slight nuisance to a real disruption during an otherwise normal day. This is a guide for the...
Helps restore gut health after antibiotics. Probiotic supplements can “restore the balance of good bacteria in the gut” after taking antibiotics, says Largeman-Roth.Another study 5looking at the influence of two single strains on results of on genitourinary dysbiosis found that vaginal flora was normalised in patients suffering from vaginal infections following probiotic intervention.
Nurish recommends taking one capsule daily with food and water. It may take two weeks for the effects to be noticeable. These probiotics do not require refrigeration. VidyaLaxme B., Rovetto A., Grau R., Agrawal R. Synergistic effects of probiotic Leuconostoc mesenteroides and Bacillus subtilis in malted ragi (Eleucine corocana) food for antagonistic activity against V. cholerae and other beneficial properties. J. Food Sci. Technol. 2014;51:3072–3082. doi: 10.1007/s13197-012-0834-5.
Ingredients: Blend of live bacteria (Lactobacillus acidophilus, Enterococcus faecium, Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus bulgaricus, Bifidobacterium longum, Corn starch), Heat-treated brown rice powder and Vegetable cellulose (capsule shell) Additionally, patients assessed their IBS symptoms using the IBS-GIS. IBS-GIS included one question about how they felt about the change in severity of symptoms in the last 7 days compared to how they felt before the intervention [ 35]. The answers were recorded based on a patient defined 7-point Likert scale. A IBS-GIS score of >4 points indicated an improvement of symptoms, <4 points indicated a worsening, and 4 points indicated no change.
Thus, the modification of the microbiota composition begins to play an increasingly important role in the treatment of IBS [ 19]. In this respect, the supplementation of IBS patients with probiotics seems very promising. Probiotics are defined as live microorganisms which, when administered at the correct dose, provide a significant health benefit to the host [ 20]. They can improve gut microbiota dysbiosis and limit pathogenic bacterial colonization [ 21]. In addition, some probiotics induce an anti-inflammatory response, while others can modulate visceral hypersensitivity or significantly improve the integrity of the intestinal epithelium and decrease the gut barrier permeability [ 22, 23, 24]. Probiotics have been reported to be effective in reducing global and specific IBS symptoms (such as abdominal pain or flatulence), as well as in improving patients’ quality of life [ 25, 26, 27, 28, 29, 30]. Although experts agree that probiotics have beneficial effects in IBS and are safe for patients, they fail to agree on the composition, dosage, and duration of probiotic intervention. A recently published meta-analysis of thirty-five randomized clinical trials showed that supplementation with multi-strain probiotics can be superior in comparison with single-strain preparations in IBS symptom improvement [ 28]. However, experts still believe that further research into the role of probiotics is required if probiotic preparations are to be adopted as a treatment for IBS.
The aim of the current RDBPC trial was to determine whether the multi-strain probiotic consists of the mixture of five Lactobacillus species ( Lactobacillus rhamnosus LR110, Lactobacillus paracasei LPC100, Lactobacillus acidophilus LA120, Lactobacillus casei LC130, Lactobacillus plantarum LP140), four Bifidobacterium ( Bifidobacterium breve BB010, Bifidobacterium longum BL020, Bifidobacterium bifidum BF030, Bifidobacterium lactis BL040) species, and Streptococcus thermophilus ST250 would be safe and effective in improving global symptom severity (measured with the use of the IBS-SSS and IBS-GIS) in patients with IBS-D. The results of our study showed the probiotic group to be superior to the placebo group in terms of primary outcomes. This was largely due to the observed benefit in improving the severity of abdominal pain and quality of life. Our results are consistent with the findings that multispecies combinations of probiotic strains have significant effects on IBS symptoms [ 28, 29, 37, 38]. Recently published systemic review and meta-analyses show that multispecies combinations of probiotic strains are superior to single strain preparations [ 28, 29], but in contrast Liang et al. conclude that single probiotics seem to be better choice as they affect specific symptoms—e.g., bloating [ 25]. Also, look for a probiotic that is encapsulated with a food source, such as inulin, so it has something to feed off of and remain viable while sitting on the shelf. Look for name-brand probiotics and read up on some research Meet the Experts: Roshini Rajapaksa, M.D., a gastroenterologist with NYU Langone Health; Frances Largeman-Roth, R.D.N., a New York City-based nutrition expert. Nurish claims this product may help combat the negative impact of environmental factors such as chronic stress, poor nutrition, or illness.
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