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When listing the amount of vitamin D in foods, most sources do not distinguish between vitamin D2 and D3. Some foods will contain a mixture of both forms. The following foods are rich in vitamin D, and since they are animal sources, they contain mainly D3: As a result, as much as 50% of adults and children in the world suffer from a vitamin D deficiency. People that are older or darker skin may have trouble absorbing sunlight and therefore may need to turn to a supplement or may need to incorporate vitamin D-rich foods in their diet. Diet
If you are taking the chewable tablet or wafers, chew the medication thoroughly before swallowing. Do not swallow whole wafers. Doctors often favor the supplement because of the dangers of UV rays and the difficulty of getting vitamin D from diet alone. Oily fish is the best source of D3, but few people want to eat fish daily. Vitamin D is found in two different forms; ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), each of which differs slightly in terms of chemical structure. “Vitamin D3 is obtained from animal sources, whereas vitamin D2 is mainly from fungal sources,” explains John White, Ph.D., chair of the department of physiology at McGill University in Montreal and a molecular biologist who has conducted extensive research on vitamin D.Low circulating vitamin D levels have been associated with lower total testosterone levels in males. Vitamin D supplementation could potentially improve total testosterone concentration, although more research is needed. [27] Other diseases [ edit ] Some symptoms of Excess Vitamin D include Constipation, Fatigue, Dehydration, Vomiting and decreased appetite. Before taking vitamin D, tell your doctor or pharmacist if you are allergic to it; or to other vitamin D products (such as calcitriol); or if you have any other allergies. This product may contain inactive ingredients (such as peanut/soy), which can cause allergic reactions or other problems. Talk to your pharmacist for more details. To find out if you have low vitamin D levels, your doctor will give you a blood test. If your levels are severely low, they may prescribe a loading dose course of vitamin D. This is a high strength dose that is only available on prescription.
In general, vitamin D functions to activate the innate and dampen the adaptive immune systems with antibacterial, antiviral and anti-inflammatory effects. [82] [83] Low levels of vitamin D appear to be a risk factor for tuberculosis, [84] and historically it was used as a treatment. [85]
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Speaking with your doctor can help determine the right amount of vitamin D for you. Blood samples are needed to run a 25-hydroxy (or 25-OH) vitamin D test. This blood test is best way to determine how much Vitamin D is in your body. Vitamin D is very similar to calcitriol. Do not use medications containing calcitriol while using vitamin D. Keeping a healthy store of vitamin D gives added protection to such diseases as cancer, multiple sclerosis, and type 1 diabetes. Health Canada published recommended dietary intakes (DRIs) and tolerable upper intake levels (ULs) for vitamin D based on the jointly commissioned and funded Institute of Medicine 2010 report. [58] [116] Australia and New Zealand [ edit ]
Osteomalacia is a disease in adults that results from vitamin D deficiency. [1] Characteristics of this disease are softening of the bones, leading to bending of the spine, proximal muscle weakness, bone fragility, and increased risk for fractures. [1] Osteomalacia reduces calcium absorption and increases calcium loss from bone, which increases the risk for bone fractures. Osteomalacia is usually present when 25-hydroxyvitamin D levels are less than about 10 ng/mL. [51] Although the effects of osteomalacia are thought to contribute to chronic musculoskeletal pain, there is no persuasive evidence of lower vitamin D levels in people with chronic pain [52] or that supplementation alleviates chronic nonspecific musculoskeletal pain. [53] Osteomalacia progress to osteoporosis, a condition of reduced bone mineral density with increased bone fragility and risk of bone fractures. Osteoporosis can be a long-term effect of calcium and/or vitamin D insufficiency, the latter contributing by reducing calcium absorption. [2] Use of supplements [ edit ] Getting enough vitamin D helps your body to lose fat while building muscle and strength. Studies have also found that those deficient in vitamin D may experience chronic muscle pain, achiness, and fatigue. 4) Diabetes a b c "Cholecalciferol (Professional Patient Advice) - Drugs.com". www.drugs.com. Archived from the original on 30 December 2016 . Retrieved 29 December 2016. Pestoff DECAL Possum Bait - Rentokil Initial Safety Data Sheets" (PDF). Archived from the original (PDF) on 15 January 2021 . Retrieved 10 May 2020.In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. The upper tolerable limit for supplementation is 4,000 International Units per day, according to Dr. White. And while he does note that this amount is most likely conservative, 4,000IU is still more than most people need to take. A study published in 2017 assessed the prevalence of high daily intake levels of supplemental vitamin D among adults ages 20+ in the United States, based on publicly available NHANES data from 1999 through 2014. Its data shows the following: Very good! Vitamin D is essential to your overall health and making sure you get enough is paramount to your well-being. Before you get started, it is important to know that there are different types of vitamin D: vitamin D3 and vitamin D2. Vitamin D toxicity is rare. [24] It is caused by supplementing with high doses of vitamin D rather than sunlight. The threshold for vitamin D toxicity has not been established; however, according to some research, the tolerable upper intake level (UL) is 4,000 IU/day for ages 9–71 [156] (100 μg/day), while other research concludes that, in healthy adults, sustained intake of more than 50,000 IU/day (1250 μg) can produce overt toxicity after several months and can increase serum 25-hydroxyvitamin D levels to 150 ng/mL and greater. [24] [157] Those with certain medical conditions, such as primary hyperparathyroidism, [158] are far more sensitive to vitamin D and develop hypercalcemia in response to any increase in vitamin D nutrition, while maternal hypercalcemia during pregnancy may increase fetal sensitivity to effects of vitamin D and lead to a syndrome of intellectual disability and facial deformities. [158] [159]
Okamura WH, Elnagar HY, Ruther M, Dobreff S (1993). "Thermal [1,7]-sigmatropic shift of previtamin D 3 to vitamin D 3: synthesis and study of pentadeuterio derivatives". Journal of Organic Chemistry. 58 (3): 600–610. doi: 10.1021/jo00055a011. Other possible agencies with claim guidance: Japan FOSHU [113] and Australia-New Zealand. [114] Dietary intake [ edit ] United KingdomWhile it’s possible to consume too much vitamin D3, it’s rare. “Vitamin D toxicity from supplementation exists but you have to try really, really, really hard,” says Dr. White. “For example, there are clinical trials where patients are given 100,000 to even 600,000 IUs (International Units) in bolus doses without side effects.” A systematic review of clinical studies found an association between low vitamin D levels with cognitive impairment and a higher risk of developing Alzheimer's disease. However, lower vitamin D concentrations are also associated with poor nutrition and spending less time outdoors. Therefore, alternative explanations for the increase in cognitive impairment exist and hence a direct causal relationship between vitamin D levels and cognition could not be established. [99] Schizophrenia [ edit ] During pregnancy, doses of vitamin D greater than the recommended dietary allowance should be used only when clearly needed. Discuss the risks and benefits with your doctor. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/ tongue/throat), severe dizziness, trouble breathing. According to one review, vitamin D supplementation could be associated with a reduced risk of certain infections, including influenza and COVID-19 [4] Grant WB, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. . What’s more, another study shows that having low levels of vitamin D could even be tied to a greater risk of multiple sclerosis [5] Sintzel MB, et al. Vitamin D and Multiple Sclerosis: A Comprehensive Review. Neurol Ther. 2018;7(1):59-85. . May Support Weight Management
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