Sublingual Vitamin B12 | Powder B12 Supplement | Highly Absorbable | 50g Powder | G&G Vitamins

Product Information

Oliai Araghi S, Kiefte-de Jong JC, van Dijk SC, Swart KMA, van Laarhoven HW, van Schoor NM, et al. Folic acid and vitamin B12 supplementation and the risk of cancer: Long-term follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) trial. Cancer Epidemiol Biomarkers Prev 2019;28:275-82. [ PubMed abstract] Finding the best B12 supplements can be a game-changer in replenishing your energy levels. Vitamin B12, commonly known as the energy vitamin, is vital for numerous body processes, from maintaining healthy red blood cells to supporting cognitive function. However, not all B12 supplements are created equal, and finding the best supplement for your needs is needed to ensure its efficacy. In this article, we will delve into the benefits of B12 supplements, why they are particularly important for vegans and vegetarians, and how to determine the most effective forms and appropriate dosages. Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: A review of literature. Eur J Clin Nutr 2014;68:541-8. [ PubMed abstract] Biotin is also found in a wide range of foods, but only at very low levels. What happens if I take too much biotin?

Gastric acid inhibitors include proton pump inhibitors, such as omeprazole (Prilosec) and lansoprazole (Prevacid), and histamine 2-receptor antagonists, such as cimetidine (Tagamet) and ranitidine (Zantac). These drugs are used to treat gastroesophageal reflux disease and peptic ulcer disease. They can interfere with vitamin B12 absorption from food by slowing the release of gastric acid into the stomach and thereby lead to vitamin B12 deficiency [ 99-101]. Metformin U.S. Department of Agriculture, Agricultural Research Service. What We Eat in America, 2017-2018. 2020.

Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A, et al. Homocysteine and dementia: An international consensus statement. J Alzheimers Dis 2018;62:561-70. [ PubMed abstract] McCleery J, Abraham RP, Denton DA, Rutjes AW, Chong LY, Al-Assaf AS, et al. Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment. Cochrane Database Syst Rev 2018;11:CD011905. [ PubMed abstract] We have touched upon this briefly at the start of this article, but Shona breaks down the two forms for us: "Vitamin B12 is mainly available in two forms, cyanocobalamin and methylcobalamin. Cyanocobalamin is converted by the body into methylcobalamin, which is the active form of Vitamin B12 that the body uses and is therefore considered to be easier for the body to absorb. Some people have a problem converting cyanocobalamin into its active form, so taking it in the form of methylcobalamin is considered better for them too." Are there any potential side effects or interactions to be aware of when taking B12 supplements? Approximately 24% of men and 29% of women reported using a dietary supplement containing vitamin B12 in NHANES 2017–2018 [ 31]. The proportion in children ranged from 30% of those age 2–5 years to 10% of adolescents age 12–19. Mean vitamin B12 intakes among supplement users from both foods and supplements were 290.3 mcg for men age 20 and older, 402.5 mcg for women, and from 26.6 to 36.0 mcg for children. Vitamin B12 Deficiency Other ingredients: soybean oil, gelatin, glycerin, yellow beeswax, water, rapeseed lecithin, colors added (including carmine)

Vitamin B12 has the potential to interact with certain medications. In addition, several types of medications might adversely affect vitamin B12 levels. A few examples are provided below. Individuals taking these and other medications on a regular basis should discuss their vitamin B12 status with their health care providers. Gastric acid inhibitors Wu Y, Zhang L, Li S, Zhang D. Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutr Rev. 2022 Feb 10;80(3):351-366. [ PubMed abstract] The FNB did not establish a UL for vitamin B12 because of its low potential for toxicity [ 1]. Even at large doses, vitamin B12 is generally considered to be safe because the body does not store excess amounts. Interactions with MedicationsIncludes a variety of vegetables; fruits; grains (at least half whole grains); fat-free and low-fat milk, yogurt, and cheese; and oils. Li S, Guo Y, Men J, Fu H, Xu T. The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis. BMC Geriatr. 2021;21:367. doi: 10.1186/s12877-021-02253-3 Vitamin B12 is naturally found in animal products such as meat, fish, eggs, and dairy - as a result; it’s recommended that vegans and vegetarians incorporate Vitamin B12 supplements into their diet, given that most plant-based foods are generally a poor source of B12.

Gomollón F, Gargallo CJ, Muñoz JF, Vicente R, Lue A, Mir A, et al. Oral cyanocobalamin is effective in the treatment of vitamin B12 deficiency in Crohn's disease. Nutrients 2017;9:308. [ PubMed abstract] Women who cannot get pregnant and men should be able to get all the folate they need by eating a varied and balanced diet.The natural forms of B12 are called methylcobalamin, adenosylcobalamin, and hydroxycobalamin. These forms have a greater bioavailability (absorption) and are considered the preferred form in supplements. However, the synthetic cyanocobalamin form can still be used for B12 supplements especially if absorption is not an issue. Taking 200mg or more a day of vitamin B6 [LK2] can lead to a loss of feeling in the arms and legs known as peripheral neuropathy. Best value Vitamin B12 supplement: Holland and Barrett High Strength B12 - view on Holland and Barrett

Taking 40mg or less a day of riboflavin supplements is unlikely to cause any harm. Niacin (vitamin B3)Exclusively breastfed infants of women who consume no animal products might have very limited reserves of vitamin B12 and can develop vitamin B12 deficiency, sometimes very early in life [ 56]. The infant’s deficiency can be severe, especially if the mother’s deficiency is severe or caused by pernicious anemia; sometimes, the mother’s own deficiency is clinically mild and not recognized. Undetected and untreated vitamin B12 deficiency in infants can result in neurological damage, failure to thrive, developmental delays, and anemia [ 2, 56, 57]. The reasons include the small amounts of vitamin B12 in the breast milk of vegan mothers as well as the limited amounts of vitamin B12 crossing the placenta in these women during fetal development. Vitamin B12 and Health Most people in the United States consume adequate amounts of vitamin B12. Data from the 2013–2016 National Health and Nutrition Examination Survey (NHANES) show that only 3% of U.S. men had intakes from food and beverages below the EAR for vitamin B12 of 2 mcg, and the rate for women was 8% [ 30]. We support supplements that are evidence-based and rooted in science. We value certain product attributes that we find to be associated with the highest quality products. We prioritize products that are third-party tested and certified by one of three independent, third party certifiers: USP, NSF, or ConsumerLab.com. The average vitamin B12 level in the breast milk of women with vitamin B12 intakes above the RDA is 0.44 mcg/L [ 14]. The U.S. Food and Drug Administration (FDA) specifies that infant formulas sold in the United States must provide at least 0.15 mcg vitamin B12 per 100 kcal [ 15].